Hey Barry,
My family are at the very top of Scotland and I live at the very south of England so I have done this joutnry many times. But I don't share Sev's restraint. I drive the 640 miles through the night so as to miss all the traffic, Leaving at about 7pm and arriving as dawn breaks over the mointains at 6am with 3 or 4 stops and an hours sleep.
But anyway, fuel... For the 640 miles I will start on a full tank, have to fill up 4 times and at my destination, I will normally have quarter - half a tank left. Now sorry, I don't pay any notice to MPG because im not driving my car for best economy.. I drive it because I love it and if fuels costs, then it costs. But with the open bare roads... I might spend some time at 120mph and generally cruising at 80-100mph.
So to give you what I would see as the most you could do, 640 miles, 3 and a half tanks but driving generally at 80-100mph with spots of more than that.
If since you're talking about MPG, I reckon you don't like I do, you may find yourself being able to do such a journey on 2 tanks of fuel for the 600 miles.
Hope this will give you a 'no more than' perspective.
Mac